丁  燕

       副教授/碩導

個人簡介：

       2018年10月-現在，伟德官网下app官方网站，伟德官网下app官方网站，副教授

       2022年10月-2023年10月，英國卡迪夫大學，化學院，訪問學者

       2017年03月-2019年02月，大連理工常熟研究院有限公司，博士後

       2011年08月-2018年09月，伟德官网下app官方网站，伟德官网下app官方网站，講師

       2010年02月-2011年01月，韓國忠南國立大學，醫藥品開發研究所，博士後
       2006年08月-2010年02月，韓國忠南國立大學，藥學院，藥學博士

       2003年09月-2006年06月，吉林農業大學，中藥材學院，醫學碩士

       1999年09月-2003年06月，吉林農業大學，中藥材學院，理學學士

社會兼職：

研究方向：

       天然産物化學與功能性；食品營養性與健康關系；食品質量控制與安全性

科研項目：

         主持并參與國家、省、市縱向和橫向科研項目多項，目前承擔的主要科研項目：

       （1）遼甯省科技計劃博士啟動基金：基于MC3T3-E1、BMMs的細胞水平抗骨質疏松藥效評價體系的構建及15種藥食兩用中藥的活性評價（20121097），4萬。

       （2）遼甯省教育廳科技研究一般項目：韓茵陳中促進成骨細胞MC3T3-E1分化萜類物質的研究（L2012183），3萬。

       （3）教育部留學回國人員科研啟動基金：基于MC3T3-E1的蓮藕有效成分促進骨形成作用機理研究（教外司留[2013]693号），3萬。

       （4）大連市高層次人才項目：基于色譜分析分離平台的中藥化學組分、成分庫構建關鍵技術研究（2016RQ064），10萬。

       （5）遼甯省教育廳基本科研項目：基于工業色譜裝備的天然産物化學分離制備平台的構建（2016J008），10萬。

       （6）遼甯省自然科學基金面上項目：基于HPLC-MS技術及化學計量學方法硫磺熏蒸對人參特征成分影響機制研究（2021-MS-299），5萬。

       （7）橫向課題：3種藥茶的質量指标篩選及測試分析研究（中國标準化研究院），20萬。

出版著作和論文：

論著：

       1. 《食品感官評價》，參編

       2.  《中國菌物藥》，參編

主要代表論文:

       (1) Li Yaxin, Zhou Zheng, Wu Qi, Chen Baoguo, Ye Shuhong, Cui Yuna,Ding Yan*. Untargeted metabolomics combined with vitro antioxidant to comprehensively evaluate the effect of sodium sulfite immersion on the holistic quality of mung bean sprouts. 2024. Journal of Food Science. (SCI, 3.9)

       (2) Li Yaxin, Chen Baoguo, Ye Shuhong, Wu Qi, Zhu Lin,Ding Yan*. Discrimination of untreated and sodium sulfite treated bean sprouts by Fourier transform infrared spectroscopy and chemometrics. 2024. Food Additives & Contaminants: Part A. (SCI, 2.9)

       (3) Chen Baoguo, Li Yaxin, Li Wei, Ye Shuhong, Zhu Lin,Ding Yan*. Antitumor Activity and Mechanism of Terpenoids in Seaweeds Based on Literature Review and Network Pharmacology. Advanced Biology. 2024, 8(3), e2300541.  (SCI, 3.7)

       (4) Chen Jialiang, Zhou Zheng, Li Ping, Ye Shuhong, Li Wei, Li Ming, Zhu Lin,Ding Yan*. Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology. Foods. 2023, 12(16), 3000. (SCI, 5.2)

       (5) Yousuf Sabiha, Liu He, Yingshu Zhang, Zahid Danish, Ghayas Hassan, Li Ming*,Ding Yan*, Li Wei*. Ginsenoside Rg1 modulates intestinal microbiota and supports re-generation of immune cells in dexamethasone-treated mice. Acta microbiologica et immunologica Hungarica. 2022, 69(4), 259-269. (SCI, 2.298)

       (6) Li Ping, Sun Hao, Li Wei, Wu Qi, Ye Shuhong, Zhu Jingbo,Ding Yan*. Isolation and purification of 12 flavonoid glycosides from Ginkgo biloba extract using sephadex LH-20 and preparative high-performance liquid chromatography. Zeitschrift für Naturforschung C. 2022, 78(1-2), 73-81. (SCI. 1.885)

       (7) Chen Jialiang, Li Pin, Ye Shuhong, Li Wei, Li Ming,Ding Yan*. Systems pharmacology-based drug discovery and active mechanism of phlorotannins for type 2 diabetes mellitus by integrating network pharmacology and experimental evaluation. Journal of food biochemistry. 2022, 46(12), e14492. (SCI, 3.6554)

       (8) Li Ping, Zhang Yanna,Ding Yan*, Wu Qi, Liu Zhaofang, Zhao Penghui, Zhao Guojing, Ye Shuhong*. Discrimination of raw and sulfur-fumigated ginseng based on Fourier transform infrared spectroscopy coupled with chemometrics. Microchemical Journal. 2022, 181, 107767. (SCI, 5.304)

       (9) Wang Bin,Ding Yan*, Zhao Penghui, Li Wei, Li Ming, Zhu Jingbo, Ye Shuhong*. Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoids. Computers in biology and medicine. 2022, 143, 105241. (SCI, 6.698)

       (10) Wang Fanfan, Ye Shuhong*,Ding Yan*, Ma Zhiyang, Zhao Qike, Zang Min, Li Yue. Research on structure and antioxidant activity of polysaccharides from Ginkgo biloba leaves. Journal of Molecular Structure. 2022, 1252, 132185. (SCI, 3.841)

       (11) 朱靖博*，王琳，丁燕，王振中，蕭偉. 二維液相色譜分離制備熱毒甯注射液主要成分. 伟德官网下app官方网站學報. 2021, 40(04): 247-252.

       (12) 王玥，丁燕*，朱靖博. 三七中皂苷類标準物質的規模化制備分離. 伟德官网下app官方网站學報. 2021, 40(05): 325-328.

       (13) 吳金倩，朱靖博*，丁燕*，肖偉. 補骨脂中化合物系統性分離制備. 天然産物研究與開發. 2020, 32:38-46

       (14) Zhang Yanna, Wang Bin, Zhao Penghui, He Fan, Xiao Wei, Zhu Jingbo,Ding Yan*. A comprehensive evaluation protocol for sulfur fumigation of ginseng using UPLC-Q-TOF-MS/MS and multivariate statistical analysis. LWT: Food science and technology. 2021, 145, 111293 (SCI, 4.006) 

       (15) Wang Fengqi, Zhang Yanna, Wu Qi, Xiao Wei, Zhu Jingbo,Ding Yan*. Purity determination and uncertainty estimation of natural products sourcing chemical reference substances by high-performance liquid chromatography and differential scanning calorimetry. Microchemical journal. 2021, 166, 106257 (SCI, 3.594) 

       (16) Li Yan,Ding Yan*, Xiao Wei, Zhu JingBo*. Investigation on the active ingredient and mechanism ofCannabis SativaL. for treating epilepsy based on network pharmacology technology. Biotechnology & Biotechnological equipment. 2021, 35(1), 994-1009 (SCI, 1.227) 

       (17) Yajie Zhu,Yan Ding*,·Tian Dongxu, Li Yan, Zhuang Linwu, Wang Yinpeng, Xiao Wei, Zhu Jingbo *. Theoretical design and mechanism research of molecularly imprinted polymers for steviol glycosides. Journal of Molecular Modeling. 2021, 8 (on line) (SCI, 1.346) 

       (18) Zhu Jingbo，Cui Weibin，Xiao Wei，Ding Yan*，Huang Wenzhe，Tu Pengfei，Wang Yonghua. Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system. Journal of Separation Science. 2018, 41: 2432–2440. （SCI, 2.415）

       (19) 朱靖博*，籍立新，肖 偉，丁燕*，黃文哲，屠鵬飛，王永華. 反相二維色譜制備甘草中的黃酮類化合物. 中草藥. 2018, 49(9), 2033-2040

       (20) 朱靖博*，李文玉，肖 偉，丁燕*，黃文哲，屠鵬飛，王永華. 反相二維液相色譜制備五味子中的木脂素. 色譜. 2018, 36(5), 464-473.

       (21) 丁燕，王楓琦，張開梅，張立鵬，蒼小鑫，杜香琳，朱靖博*，蕭偉. 基于QSAR模型的食品譜效關系研究：以植物黃酮為例. 中國食品學報. 2018，18（8）,239-246.（EI）

       (22) 丁燕，張立鵬，王靖，張開梅，王楓琦，蕭偉，朱靖博*. 基于微核試驗及彗星試驗評價丹酚酸A、丹酚酸B及原兒茶醛的抗突變活性. 中國食品學報. 2018,18（9）,311-316.（EI）

       (23) 蒼小鑫，趙小明，鐘潤濤，王文霞，尹恒，朱靖博，丁燕*. 基于液滴微流控的殼寡糖植物免疫誘導劑熒光檢測. 農業工程學報. 2017,33(2)：302-307.（EI）

       (24) 徐飛飛，丁燕*，張海東，郭盈瑩，曲丹，寇自農，肖偉，朱靖博*，15 種藥食同源中 藥提取物抗氧化及抗骨質疏松活性研究. 中國食品學報，2017 , 17 (6) :240-248 .（EI）

       (25) 丁燕*，孫浩，徐飛飛，曲丹，王楓琦，蕭偉，朱靖博*，基于雌激素靶标的藥食同源 中藥抗骨質疏松活性網絡藥理學初探. 中國食品學報，2017, 17(12): 182-192. （EI）

       (26) Xu Fei Fei, Ding Yan*, Guo Ying Ying, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Anti-osteoporosis effect of Epimedium via an estrogen-like mechanism based on a system-level approach. Journal of Ethnopharmacology, 2016, 177: 148-160.（SCI, 2.998）

       (27) Ding Yan, Qu Dan, Zhang Kai-Mei, Cang Xiao-Xin, Kou Zi-Nong, Xiao Wei, Zhu Jing-Bo Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review, Journal of Asian Natural Products Research, 2016 , 19 (1) :53-100（SCI, 1.009）

       (28) Guo Ying Ying, Ding Yan*, Xu Fei Fei, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Systems pharmacology-based drug discovery for marine resources: An example using sea cucumber (Holothurians). Journal of Ethnopharmacology, 2015, 165: 61-72.（SCI, 2.998）

       (29) Ding Yan, Kim Jeong Ah, Yang Seo Young, Kim Won-Ki, Lee Sang Hyun, Jang Hae Dong, Kim Young Ho*, Antioxidative Sesquiterpenes from Artemisia iwayomogi. Bulletin of the Korean Chemical Society, 2011, 32(9): 3493-3496. (SCI, 1.257)

       (30) Ding Yan, Wu En Qi, Liang Chun, Chen Jian bo, Kang Jong Seong, Park Kyung Lae, Bae KiHwan, Kim Young Ho*, Quality evaluation and comparative study of Cinnamomi Ramulus and Cinnamomi Cortex in different countries based on HPLC fingerprintchromatogram and pattern analysis. Food Chemistry, 2011, 127, 755-760. (SCI, 3.146)

       (31) Ding Yan, Liang Chun, Kim Jun Ho, Lee Young-Mi, Hyun Jae-Hee, Kang Hee-Kyoung, Kim Jeong-Ah, Min Byung Sun, Kim Young Ho*, Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters, 2010, 20(5): 1528-1531. (SCI, 2.531)

       (32) Ding Yan, Liang Chun, Nguyen Huu Tung, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Chemical constituents from Acer mandshuricum and their effects on the function of osteoblastic MC3T3-E1 cells. Bulletin of the Korean Chemical Society, 2010, 31(4): 929-933. (SCI, 1.257) 

       (33) Ding Yan, Liang Chun, Yang Seo Young, Chan Jeong, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells. Biological & Pharmaceutical Bulletin, 2010, 33(8): 1448-1453. (SCI, 1.765) 

       (34) Ding Yan, Liang Chun, Yang Seo Young, Kim Jun Ho, Lee Young Mi, Kim Young Ho*, Iwayoside A, a new Diterpene Glycoside from Artemisia iwayomogi Kitamura that enhances IL-2 Secretion. Bulletin of the Korean Chemical Society, 2010, 31(8): 2422-2423. (SCI, 1.257) 

       (35) Ding Yan, Nguyen Huu Tung, Choi Eun Mi, Bae Kihwan, Kim Young Ho, Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 Cells. Planta medica, 2009, 75(2), 158-62. (SCI, 1.960) 

       (36) Ding Yan, Nguyen Huu Tung, Kim Sung In, Kim Ha Won, Kim Young Ho*, The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris. Bioorganic & Medicinal Chemistry Letters, 2009, 19(13): 3607-3610. (SCI, 2.531) 

       (37) Ding Yan, Bao Hai Ying, Bau Tolgor, Li Yu, Kim Young Ho*, Antitumor Components from Naematoloma fasciculare. Journal of Microbiology and Biotechnology, 2009, 19(10): 1135-1138. (SCI, 2.32)

       (38) Ding Yan, Liang Chun, Choi Eun Mi, Ra Jeong Chan, Kim Young Ho*, Chemical Constituents from Artemisia iwayomogi Increase the Function of Osteoblastic MC3T3-E1Cells. Natural Product Sciences 2009, 15(4): 192-197. 

       (39) Ding Yan, Wu En Qi, Chen Jianbo, Nguyen Huu Tung, Do Thi Ha, Park Kyung Lae, Bae KiHwan, Kim Young Ho, Kang Jong Seong*, Quality evaluation of Moutan Cortex Radicis using multiple component analysis by High Performance Liquid Chromatography. Bulletin of the Korean Chemical Society, 2009, 30(10): 2240-2244. (SCI, 1.257) 

       (40) Ding Yan, BAO Hai-Ying, BAU Tolgor, LI Yu. Anti-tumor effect of Naematoloma fasciculare polysaccharide. 菌物學報, 2006, 25 (4)：611-615.

       (41) 丁燕, 圖力古爾, 包海鷹. 沿絲傘屬真菌化學成分與藥理學研究概況. 菌物學報, 2004, 23 (4)：605-611.

       (42) 包海鷹, 丁燕, 李登科, 李玉. 膠陀螺發酵液的研究. 菌物研究, 2003，1(1)：40-43.

在讀學生人數：

       在讀碩士研究生7名。

畢業學生人數：

       已畢業碩士研究生15名。